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safe2176391 artist:bluse406 sci-twi31380 spike92463 spike the regular dog3211 twilight sparkle358120 dog13560 equestria girls256169 g42031048 my little pony equestria girls: rainbow rocks19988 adventure in the comments1346 angry36691 boots33475 clothes635390 collar48006 cute266046 doggy dragondox84 duality5448 feet54564 female1804923 glare9057 glasses88848 hallway1277 hand on hip13421 high heels17238 high res407918 hilarious in hindsight3831 lab coat2938 leash10591 legs11914 lockers2725 looking at each other34395 open mouth237959 sandals5682 self paradog10 self paradox4098 self ponidox10386 shirt40529 shoes59556 show accurate26829 signature44209 skirt55641 spikabetes2665 spike the dog3029 toes9349 twiabetes15312 twilight sparkle (alicorn)149553 twolight1572

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Background Pony #2F23
If the trailers (which, need I remind you, are just trailers) are of any indication then Science Twilight would be faced with a angry Twilight Prime (like Twilight’s Kingdom Part 2 angry).
Background Pony #E6E2
Human Twilight: I found you!
 
Twilight Prime: What do you want?
 
Human Twilight: Strange things are happening in this school and my readings point to myself as the culprit.
 
Twilight Prime: What’s going to happen to me now?
 
Human Twilight: We’re going to my lab… I have a present for you. Well it’s more like a medical procedure, actually it’s more like a medical experiment.