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safe2283899 artist:bluse408 sci-twi32815 spike95585 spike the regular dog3313 twilight sparkle372034 dog14411 equestria girls268420 g42125556 my little pony equestria girls: rainbow rocks20398 adventure in the comments1354 angry38675 boots37112 clothes680422 collar51354 cute280642 doggy dragondox84 duality5800 feet57767 female1914673 glare9219 glasses96960 hallway1366 hand on hip14850 high heels18473 high res411928 hilarious in hindsight3926 lab coat3122 leash11191 legs12644 lockers2898 looking at each other39042 open mouth258072 sandals6389 self paradog10 self paradox5108 self ponidox11061 shirt45161 shoes66080 show accurate28163 signature50876 skirt59788 spikabetes3472 spike the dog3145 toes10266 twiabetes16340 twilight sparkle (alicorn)155433 twolight1661

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Background Pony #2F23
If the trailers (which, need I remind you, are just trailers) are of any indication then Science Twilight would be faced with a angry Twilight Prime (like Twilight’s Kingdom Part 2 angry).
Background Pony #E6E2
Human Twilight: I found you!
 
Twilight Prime: What do you want?
 
Human Twilight: Strange things are happening in this school and my readings point to myself as the culprit.
 
Twilight Prime: What’s going to happen to me now?
 
Human Twilight: We’re going to my lab… I have a present for you. Well it’s more like a medical procedure, actually it’s more like a medical experiment.