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safe2279864 artist:bluse408 sci-twi32880 spike95500 spike the regular dog3298 twilight sparkle372864 dog14359 equestria girls269213 g42137010 my little pony equestria girls: rainbow rocks20429 adventure in the comments1354 angry38705 boots37097 clothes684534 collar51841 cute282006 doggy dragondox84 duality5795 feet57913 female1922216 glare9202 glasses96485 hallway1364 hand on hip14962 high heels18681 high res413705 hilarious in hindsight3912 lab coat3125 leash11209 legs12750 lockers2913 looking at each other38860 open mouth259395 sandals6365 self paradog10 self paradox5061 self ponidox11030 shirt45491 shoes66164 show accurate28426 signature50153 skirt60621 spikabetes3410 spike the dog3135 toes10288 twiabetes16314 twilight sparkle (alicorn)155528 twolight1660

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Background Pony #2F23
If the trailers (which, need I remind you, are just trailers) are of any indication then Science Twilight would be faced with a angry Twilight Prime (like Twilight’s Kingdom Part 2 angry).
Background Pony #E6E2
Human Twilight: I found you!
 
Twilight Prime: What do you want?
 
Human Twilight: Strange things are happening in this school and my readings point to myself as the culprit.
 
Twilight Prime: What’s going to happen to me now?
 
Human Twilight: We’re going to my lab… I have a present for you. Well it’s more like a medical procedure, actually it’s more like a medical experiment.