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safe2263694 artist:bluse408 sci-twi32688 spike95040 spike the regular dog3288 twilight sparkle370764 dog14237 equestria girls267411 g42123752 my little pony equestria girls: rainbow rocks20393 adventure in the comments1355 angry38427 boots36494 clothes676207 collar51299 cute279534 doggy dragondox84 duality5754 feet57442 female1904813 glare9171 glasses95359 hallway1350 hand on hip14796 high heels18491 high res412782 hilarious in hindsight3902 lab coat3081 leash11100 legs12678 lockers2891 looking at each other38167 open mouth256279 sandals6312 self paradog10 self paradox4911 self ponidox10927 shirt44871 shoes65085 show accurate28164 signature48939 skirt59984 spikabetes3355 spike the dog3125 toes10184 twiabetes16158 twilight sparkle (alicorn)154652 twolight1647

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Background Pony #2F23
If the trailers (which, need I remind you, are just trailers) are of any indication then Science Twilight would be faced with a angry Twilight Prime (like Twilight’s Kingdom Part 2 angry).
Background Pony #E6E2
Human Twilight: I found you!
 
Twilight Prime: What do you want?
 
Human Twilight: Strange things are happening in this school and my readings point to myself as the culprit.
 
Twilight Prime: What’s going to happen to me now?
 
Human Twilight: We’re going to my lab… I have a present for you. Well it’s more like a medical procedure, actually it’s more like a medical experiment.