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safe2257671 artist:bluse408 sci-twi32601 spike94869 spike the regular dog3284 twilight sparkle369856 dog14163 equestria girls266720 g42118183 my little pony equestria girls: rainbow rocks20382 adventure in the comments1352 angry38279 boots36259 clothes673181 collar51069 cute278584 doggy dragondox84 duality5742 feet57212 female1897834 glare9166 glasses94916 hallway1344 hand on hip14725 high heels18404 high res412425 hilarious in hindsight3902 lab coat3077 leash11047 legs12627 lockers2881 looking at each other37922 open mouth255152 sandals6290 self paradog10 self paradox4872 self ponidox10902 shirt44524 shoes64689 show accurate28032 signature48672 skirt59628 spikabetes3317 spike the dog3121 toes10107 twiabetes16098 twilight sparkle (alicorn)154363 twolight1646

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Background Pony #2F23
If the trailers (which, need I remind you, are just trailers) are of any indication then Science Twilight would be faced with a angry Twilight Prime (like Twilight’s Kingdom Part 2 angry).
Background Pony #E6E2
Human Twilight: I found you!
 
Twilight Prime: What do you want?
 
Human Twilight: Strange things are happening in this school and my readings point to myself as the culprit.
 
Twilight Prime: What’s going to happen to me now?
 
Human Twilight: We’re going to my lab… I have a present for you. Well it’s more like a medical procedure, actually it’s more like a medical experiment.