Do a flip!

Ah Azumanga Daioh, this brings back memories

@nambona890  
Because there is no escape

Azumadden Daeiou

why did someone make this  
and what am i doing back on this site as a former brony in the first place

@Background Pony #6BA5  
Wait, we need Gakkou Gurashi (School Live!) MLP Crossover….so far…I think  
Pinkie Pie - Yuki  
Rainbow Dash - Kurumi  
Applejack - Miki
 
I don’t know about the rest though….

Rarity and Twilight are by far the most amusing of these.

@Soda Fizz  
John Madden! John Madden! John Madden!  
AEIOU

@Soda Fizz  
It’s not ghey if it’s on the moon.

@SeraphimDawn  
Yep. xD

@Soda Fizz  
Moonbase Alpha?

@Lunalove  
Then we can do with
 
Rainbow Dash: Konata Izumi  
Derpy: Tsukasa Hiragii  
Twilight Sparkle: Kagami Hirgaii  
Fluttershy: Miyuki Takara  
Applejack: Patricia Martin  
Pinkie Pie: Misao Kusakabe  
Rarity: Minami Iwasaki
 
In Lucky Star! Any more Animes we can do

I throw ponies in the air sometimes!  
Singing AYEOH!

Lu-la-lu

All it needs next is:
 
Derpy: Yui (Gibson Les Paul; ‘GITAH!’)  
Fluttershy: Mugi-chan (KORG Triton Extreme keyboard)  
Rarity: Mio (Fender Jazz Bass; ‘Elizabeth’)  
Rainbow Dash: Ritsu (Yamaha drums, Zildjian cymbals)  
Twilight Sparkle: Azu-nyan (Fender Mustang guitar; ‘Muttan’)
 
Sawako-sensei: (Princess Molestia; Gibson Flying V)
 

 
…in “K-PON!”
 
‘Please don’t say you are Hayzy…!’

Huh. Well, I just linked it because AzuDai OP. There are other vids of it out there as well. If they actually believe that anti-vaccine bullshit, I feel sorry for them. /shrug

@DJLowrider  
The last ten seconds of the video are just a message saying saying the flu vaccine contains poisons. Their other videos are also Azumanga with random bits of anti-vaccine propaganda inserted for no reason, and references to an old blog (theflucase) that was apparently run by a conspiracy theorist and shut down for inciting violent anti-vaccine action.
 
It is completely inexplicable, but I think they’re serious.

Someone’s been tossing ponies into the air.

@Soda Fizz  
Gummy is the only one who can be Chiyo-Dad.
 
 
@Background Pony #BF7B  
Wow, I even heard the sound effects and music in my head for that. Awesome.

When I see this, all I think of is this:  

@KitHavoc  
Ayumu Kasuga, a.k.a. Osaka, is Pinkie Pie (or Derpy).  
Sakaki is Fluttershy.  
Tomo and Kagura are Rainbow Dash and Applejack, interchangeably.

Pinkie - Chiyo, should be Twilight.  
Rarity - Yomi, I can see this.  
Applejack - Kagura, Rainbow Dash fits this role.  
Fluttershy - Osaka, I can see this.  
Twilight - Sakaki, Applejack would be perfect as Sakaki.  
Rainbow Dash - Tomo, hard choice but I think she should be Pinkie.

@lasty
 
When Chiyo-chichi is voiced by Norio Wakamoto - as is the Genetic Beast ‘TAMA’ in “Kiddy Girl-and”, a Dyson vacuum cleaner in “Haiyore! Nyaruko-san W”, and a yellow ball-thing in “Nin-Nin-Ga Shinobuden” also by him - then anything makes sense. X3

@fixman88
 
The uploader for that copy of the OP put up a “Don’t take the swine flu vaccine!” message on Yukari’s chalkboard at one point. Honestly I’ve never thought it was something to take seriously since, y’know, AzuDai. It’s the sort of dumb shit Yukari would tell her students that we’re meant to laugh at. That’s how I took it. Of course if it’s the uploader being serious then yes it’s dumb and wrong, but again I posit that the OP sequence of an incredibly silly and adorable slice-of-life anime is not where one tries to make such a point.
 
tl;dr - pretty sure it was meant as a joke, why so serious anon?