Of the characters I watch, the vast majority are female, two are mute (Apparently Shovel, Sign), two are blind (Blooming Corals, Snowdrop), three are dyslexic (Aura, Silver Spoon, Sassy Lost), three have Marfan syndrome (Apple Bloom, Pear Butter, Sassy Lost), one has three different heart conditions (Puppysmiles), several have gigantism (Altus Bastion, Cumulonimbus, Sequoia, Specialist Sunflower, Striker Blue, Golden Age, Windbreaker, Sugary Violet, Diamonody, Invidia Nox, Summer Sunshine, Fort, Warcry, Glory Forge, Fury, Sassy Lost, Apple Bloom), several are intersex (Arcade Fever off the top of my head, among others), some are trans (Snails), at least two are undead (Puppysmiles, Frizzle Frisk), a handful are cyborgs (Blackjack, Wireless Fuzz, Hoofless, Prophecy, possibly more), some are obese (Jester Bells, Felicity Stars, Magna-Save, probably others), one is a sociopath (Cozy Glow), one is undergoing social rehabilitation (Starlight Glimmer), two were sexually abused (Boing, Threnody), at least two are psychic (Tabula Rasa, Threnody), one has an axe in her head (Chocolate Icing), and one has existence amnesia (Spur). Strangely, only 8 are canon characters, and only three of them actually have that in canon.