Even good heroes like Twilight Sparkle, the Princess of Friendship herself can also be infected by this mind-controlled aura. When corrupted into villainous mode, Twilight doesn’t recognize her friends and allies from foes and only attacks on instinct and tactics. With a combination of the Mind-Manipulation of the late King Sombra, Villainous Mode Twilight becomes a danger that equals to her human counterpart, Midnight Sparkle
 
• Twilight was brainwashed into villainous mode during the events of Fanfictions:  
“The Tournament of Darkness: Part 1”  
and “Injustice: The Red Hand 5: Celaeno and the Secret of Atlantis”