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safe2176555 artist:swain89 pinkie pie256133 rarity217733 human245944 g42031141 ask-humans-from-equestria39 breasts391626 busty pinkie pie14412 cafe789 clothes635460 comic135586 comically missing the point60 cutie mark eyes274 female1805113 glasses88859 horn191614 horned humanization8087 humanized119783 marshmelodrama994 miniskirt6879 misspelling3176 pinkie logic51 project mistletoe17 skirt55645 socks95683 striped socks28322 thigh highs59734 thigh socks986 wingding eyes40543

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Background Pony #3944
Swain’s Pinkie Pie looks more like Whitney than a humanized Pinkie Pie thanks to her twintails and striped socks.
The CLaUD
Friendship, Art, and Magic (2018) - Celebrated Derpibooru's six year anniversary with friends.
Friendship, Art, and Magic (2017) - Celebrated Derpibooru's five year anniversary with friends.
Artist -

Definately NOT a bot!
It’s probabily just the stripes and the pigtails, but something about this pinkie just says Harley Quinn to me…
Grelrik

For those not entirely related with this kind of subject, PMS is more common in women over their 40 decades, it is strange to see it happen im a 16 yeard old girl even more strange to see it on 3 girls that happen to be friends.
BigMax
Fine Arts - Two hundred uploads with a score of over a hundred (Safe/Suggestive)
The End wasn't The End - Found a new home after the great exodus of 2012

Oh.  
Of course, Pinkie gets it immediately.
 
@PonyPon  
“A lady never has an uncouth thing such as ‘PMS’! She simply has her own, natural moods.”
Background Pony #D9E3
reading back the previous comics, Pinkie is 100% correct  
that is the biggest joke :p