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safe2174199 artist:bluse406 sci-twi31343 spike92397 spike the regular dog3206 twilight sparkle357712 dog13538 equestria girls255828 g42028819 my little pony equestria girls: rainbow rocks19971 adventure in the comments1346 angry36661 boots33395 clothes634407 collar47938 cute265732 doggy dragondox84 duality5476 feet54490 female1802554 glare9054 glasses88679 hallway1274 hand on hip13381 high heels17197 high res407819 hilarious in hindsight3829 lab coat2933 leash10586 legs11892 lockers2724 looking at each other34327 open mouth237500 sandals5676 self paradog10 self paradox4065 self ponidox10366 shirt40419 shoes59412 show accurate26793 signature43994 skirt55538 spikabetes2660 spike the dog3025 toes9332 twiabetes15286 twilight sparkle (alicorn)149112 twolight1568

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Background Pony #2F23
If the trailers (which, need I remind you, are just trailers) are of any indication then Science Twilight would be faced with a angry Twilight Prime (like Twilight’s Kingdom Part 2 angry).
Background Pony #E6E2
Human Twilight: I found you!
 
Twilight Prime: What do you want?
 
Human Twilight: Strange things are happening in this school and my readings point to myself as the culprit.
 
Twilight Prime: What’s going to happen to me now?
 
Human Twilight: We’re going to my lab… I have a present for you. Well it’s more like a medical procedure, actually it’s more like a medical experiment.