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semi-grimdark38214 artist:metal-kitty637 big macintosh35034 derpy hooves59952 rainbow dash292060 rarity226734 spike95679 dragon93074 earth pony554256 pegasus547013 pony1718551 unicorn591202 g42129658 abuse11382 baseball bat1630 blood33669 comic142672 crossover75915 derpy soldier93 female1920259 heavy (tf2)602 heavy mac116 horn255741 male592914 meet the soldier10 musical instrument16276 pyro (tf2)851 rainbow scout250 raribuse674 rarispy259 scout (tf2)1217 soldier2601 soldier (tf2)882 spike pyro24 spy1486 spy (tf2)1050 stallion217406 team fortress 27277 trumpet447 wingless spike3063

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Background Pony #3CCE
@CocoaNut  
Not quite.  
I quote:
 
“Vitamin B12 /deficiency/ can potentially cause severe and irreversible damage, especially to the brain and nervous system.”
CocoaNut

@lord_derp_herpington42
 
There are hypotheses (obviously untestable) out there that say that humans only evolved sapience because we increased the amount of meat we consume a little further back. Given that B12 deficiency causes brain deterioration and B12 is found pretty much exclusively in animal sources (and completely exclusively when talking about food to which our ancestors had access), this… might carry some weight.
 
In other words, maybe these ponies became sapient because their ancestors started eating more meat than horses normally do (it’s pretty rare, but it does happen).