@Lord WyrmSpawN
People with large amounts of drug digesting enzymes can have a hard time with medicine, yes. However if you’re just resistant to the hypoxic effects of alcohol and cyanide the medicine you take might be less effected. However alcoholics and mithrildates can be resistant to the hypoxia, and have a heavy drug metabolism at the same time, which has led to failed assassination attempts before.
For fun I’m going to assume the resistance is usually to weaponized poisons. Such things usually interrupt your oxygen supply, or disrupting the function of Mitochondrion and its production of heat or ATP. One can gain a resistance to these types of poisonings by adapting and growing more mitochondria in their cells.
Being resistant to hypoxic conditions will make it easier to tolerate alcohol, and many poisons. This is before drug digesting enzymes and other mechanics of resistance are considered.
There is real life cases of alcoholics surviving multiple poisoning attempts. Including Michael Malloy, and Grigori Rasputin.
Conclusion: if you’re resistant to hypoxia, you can be more resistant to alcohol and traditional poisons. But the effects of medicine would be more effected by drug digesting enzymes. So an astounding ‘maybe’.
Disclaimer:
Alcoholics don’t always develop resistance to alcohol or other poisons. If you do nothing but drink with no space in between or care for your body, you won’t bounce back resistant, you’ll just slowly die.
Mithridiatism is paranoia induced self harm.
Exercise is the correct way to become resistant to hypoxia.